Felejtek.hu Alzheimer-kór – együttélés a demenciával

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Új demenciatípust azonosítottak

Szemlézte: Pöltz Ágnes

2019.05.20. 12:00

A demenciáról

forrás: CNN

A Brain című tudományos szakfolyóirat friss tanulmánya szerint az orvosok olyan új demenciatípust azonosítottak, ami az Alzheimer-kórnál is gyakoribb lehet az idősek körében.

 

A LATE névre keresztelt betegség gyakran olyan tünetekkel jár, mint az Alzheimer-kór, ám más módon hat az agyra. Sokszor azonban a két demenciatípus együttesen fordul elő, ilyenkor az állapot gyorsabb szellemi leépüléssel jár. 

 

Már évek óta beszámoltak az orvosok a világ különféle pontjain olyan betegekről, akik tünetei és betegségük lefolyása nem követte az Alzheimer-kórra jellemző tipikus mintázatot. Ezen esetek összegzése vezetett az új demenciatípus kategóriájának megalkotásához. 

 

Dr. Sandra Weintraub pszichiáter szerint a szakma már régóta tisztában van azzal, hogy a demencia jelensége heterogén, ám nagyon nehéz azt kimutatni, hogy pontosan mi is áll egy-egy típus jellegzetességei mögött: miért van, hogy egyesek feledékenyekké válnak, míg másoknak a nyelvi készségeik érintettek vagy éppen a viselkedésük változik meg? 

 

A LATE mozaikszó a limbic-predominant age-related TDP-43 encephalopathia nevet takarja. 
Az életkorral együtt járó demenciák nagy részében valamilyen fehérje szokott szerepet játszani, azonban betegségenként eltérő, hogy pontosan melyik. Az Alzheimer-kórban egy bizonyos protein a fő bűnös, míg a Lewy-testes demenciában egy másik. A LATE esetében a TDP-43 nevezetű fehérjét azonosították.

 

A TDP fehérje két másik, ritka betegségtípussal is összefüggésbe hozható, mégpedig az ALS-sel, illetve a frontotemporális demenciával. A LATE azonban ezeknél százszor gyakoribb, mégis alig tud róla valaki. A 80 év feletti idősek között ugyanis 20-50 százalék a betegség előfordulása - derül ki a boncolásos vizsgálatokból.

 

A friss felfedezés az Alzheimer-kór kutatásának is segíthet. Eddig ugyanis sokan kiestek az Alzheimer-gyógyszerek kísérleti szakaszából, mivel tüneteik nem mutattak javulást a kezelések hatására – feltehetően azért, mert ma már ezek a betegek LATE diagnózist kapnának. Mostantól tehát a gyógyszerkísérletek résztvevőinek toborzásakor hatékonyabban ki tudják szűrni a valóban Alzheimer-kórban szenvedőket és külön tudják majd segítségükkel tesztelni a kísérleti terápiákat. Mindez pedig megnyithatja az utat a LATE alaposabb vizsgálatának és a hatékony beavatkozások azonosításának is.

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