Veszélyes a magas koleszterinszint
Szemlézte: Pöltz Ágnes
2019.06.23. 16:00
Egy friss kutatás eredményei szerint az LDL-koleszterin (közismertebb nevén a "rossz" koleszterin) magas szintje összefüggésbe hozható a fiatalkori Alzheimer-kór kialakulásának magasabb kockázatával.
A JAMA Neurology szaklapban közzétett vizsgálatban egészséges, valamint fiatalkori Alzheimerrel élő betegek koleszterinszintjét hasonlították össze. Azoknál, akik LDL-koleszterinszintje magasabb volt, a fiatalkori demencia gyakoribb előfordulását találták. Amikor a vérmintákat genetikai elemzésnek vetették alá, az adatok arra mutattak rá, miszerint a fiatalkori Alzheimer-kórral diagnosztizált betegek körében gyakrabban fordult elő az a génváltozat, mely az LDL-koleszterin fő fehérjéjét kódolja.
A brit Alzheimer-kutatási társaság tudományos igazgatója, Dr. Jana Voigt elmondta, a tudományos területen köztudomású, hogy a magasabb koleszterinszint megnöveli az Alzheimer-kór kialakulásának kockázatát. A friss kutatás ugyanakkor azt támasztja alá, miszerint a fiatalkori, tehát 65 éves kor előtt megjelenő Alzheimer-kór esetében jelentős genetikai háttér előtt bontakozik ki a kapcsolat az emelkedett koleszterinszint és a betegség előfordulásának gyakorisága között. Kiemelte, hogy ugyan a vizsgálat nem tárt fel ok-okozati összefüggést, a két jelenség együttes előfordulásáról meggyőző bizonyítékokat szolgáltatott.
A kutató hozzátette, hogy habár ismert tény a koleszterin magasabb szintje és az Alzheimer-kór kialakulása közötti kapcsolat, a koleszterinszintet csökkentő statinok klinikai vizsgálatai eddig mégsem mutatták eddig, hogy statinokkal jól kezelhető vagy megelőzhető volna az Alzheimer.
Dr. Voigt szerint sokan tudják, hogy a magas koleszterinszint a szív-és érrendszeri betegségek kialakulása szempontjából jelentős kockázati tényezőt jelent, ám az már kevesebb ember fejében él, hogy a demencia tekintetében ugyanígy fontos szerepet játszhat. Javaslata szerint az agy egészségének megőrzése céljából a kiegyensúlyozott táplálkozás, a testsúlykontroll, a füstmentes és alkoholban mértékletes életmód és a testmozgás mellett a vérnyomás és a koleszterinszint alacsonyan tartása a leginkább célravezető.
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