Az idegsejtek öregedése lehet a kulcs több betegségben
Szemlézte: Pöltz Ágnes
2021.04.23. 12:25
Testünk legtöbb sejtjével ellentétben az idegsejtek évtizedekig élnek. Mivel ezek az agysejtjeink nem képesek örökítőanyaguk, a DNS megsokszorozására, ezért folyamatosan javítják az állományukon esett károsodásokat. Ahogyan öregednek, egyre kevésbé hatékonyak ezek a javítómechanizmusaik, ami feltételezhetően utat engedhet az Alzheimer-kór és a Parkinson-kór kialakulásának is.
A tudomány már eddig is ismerte a károsodások állandó javításának jelenségét az agyban. Egy új vizsgálat szerint ez a tevékenység azonban nem véletlenszerű, hanem vannak olyan speciális területek, amelyek a feltevések szerint különös jelentőséggel bírnak. Az idegsejtek ezeket a területeket igyekeznek elsőként rendbe hozni az örökítőanyagon.
A Science tudományos szakfolyóiratban közölt cikk egészen újszerű betekintést enged az agy öregedésének és betegségeinek genetikai hátterébe, ezzel pedig lehetőség kínálkozik ara, hogy az Alzheimer-kór, Parkinson-kór és más demenciához kapcsolódó betegségek kezelésére is hatékony beavatkozásokat alakíthassunk ki.
Dr. Rusty Gage professzor, a publikáció szerzője úgy nyilatkozott, hogy felfedezésük legfontosabb tanulsága abban áll, miszerint az agy genetikai állományában vannak olyan pontok, amik kiemelt figyelmet kapnak az agy öngyógyító folyamataiban. Ezen területek ismeretében pedig lehetővé válik majd olyan terápiák kidolgozása, amik éppen ezeket a genetikai területeket célozzák meg.
Iratkozzon fel hírlevelünkre!
Harmadik fél részére nem adjuk ki az e-mail címét!
NYOMKÖVETÉS (string) «https://work1.felejtek.hu»
(string) «{modul:wd_article}»
INCLUDE MODUL: felejtek_meta CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_meta (0,0034 mp)
INCLUDE MODUL: jsonld CALL: Andrea\Plugins\JsonLD\JsonLD::modul_json_ld (0,0001 mp)
INCLUDE MODUL: owm_daily_mobile MISSED CALL (owm_daily_mobile).
INCLUDE MODUL: felejtek_menu:1 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_menu (0,0633 mp)
INCLUDE MODUL: wd_article CALL: Andrea\Plugins\Webdoki\MagazineArticle::modul_wd_article (0,0028 mp)
INCLUDE MODUL: felejtek_box:250 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_box (0,0008 mp)
INCLUDE MODUL: felejtek_box:248 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_box (0,0006 mp)
INCLUDE MODUL: basemenu CALL: Andrea\Core\PageList::modul_basemenu (0,0003 mp)
INCLUDE MODUL: comments MISSED CALL (comments).
INCLUDE MODUL: felejtek_related_articles CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_related_articles (0,0000 mp)
INCLUDE MODUL: felejtek_suggested_articles CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_suggested_articles (0,0029 mp)
MUNKAMENET VÁLTOZÓ array (
'SID' => 'b0a319858417c96ca79dca0ee5e317cb',
'user' => 'O:16:"Andrea\Core\User":5:{s:8:"login_ok";b:0;s:13:"inner_modules";a:0:{}s:8:"template";s:0:"";s:5:"items";N;s:8:"' . "{debug_info}" . '*' . "{debug_info}" . 'props";a:4:{s:7:"message";s:0:"";s:10:"user_group";O:21:"Andrea\Core\UserGroup":4:{s:13:"inner_modules";a:0:{}s:8:"template";N;s:5:"items";N;s:8:"' . "{debug_info}" . '*' . "{debug_info}" . 'props";a:0:{}}s:15:"registered_date";s:0:"";s:8:"topic_id";a:0:{}}}',
'lang' => 'hu',
'currency' => 'huf',
'a' => 'cikk',
'p' => '1',
'article' => 671,
'template_path' => '/templates/felejtek2023',
)KIKÜLDÖTT SQL KÉRÉSEK PDO connected to localhost.
SET SESSION `character_set_client` = 'utf8' (0 sor: 0.0002 mp/0.0002 mp)
SET SESSION `character_set_connection` = 'utf8' (0 sor: 0.0001 mp/0.0003 mp)
SET SESSION `character_set_database` = 'utf8' (0 sor: 0.0002 mp/0.0005 mp)
SET SESSION `character_set_filesystem` = 'utf8' (0 sor: 0.0001 mp/0.0006 mp)
SET SESSION `character_set_results` = 'utf8' (0 sor: 0.0001 mp/0.0007 mp)
SET SESSION `character_set_server` = 'utf8' (0 sor: 0.0001 mp/0.0007 mp)
SET SESSION `collation_connection` = 'utf8_hungarian_ci' (0 sor: 0.0001 mp/0.0008 mp)
SET SESSION `collation_database` = 'utf8_hungarian_ci' (0 sor: 0.0001 mp/0.0009 mp)
SET SESSION `collation_server` = 'utf8_hungarian_ci' (0 sor: 0.0001 mp/0.0009 mp)
SET SESSION `group_concat_max_len` = 1024 (0 sor: 0.0001 mp/0.0010 mp)
SELECT * FROM `alz_core_plugin`
WHERE `domain_id` = ? AND `option_active`=1
ORDER BY `depend_nums` ASC (9 sor: 0.0007 mp/0.0017 mp)
SELECT `name`,`value` FROM `alz_core_param` WHERE domain_id = ? (18 sor: 0.0006 mp/0.0022 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0002 mp/0.0024 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0025 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0026 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0027 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0027 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0028 mp)
SELECT `name`,`value` FROM `alz_core_lang` WHERE domain_id = ? (34 sor: 0.0004 mp/0.0032 mp)
SELECT id FROM alz_core_page WHERE domain_id = ? AND permalink = ? (0 sor: 0,0004 mp/0,0036 mp)
SELECT `theme_id` FROM `alz_core_domain` WHERE `id`=1 (1 sor: 0,0004 mp/0,0039 mp)
SELECT * FROM `alz_core_theme` WHERE (`id`=2) LIMIT 1 (1 sor: 0,0002 mp/0,0042 mp)
SELECT * FROM `alz_mag_topic` ORDER BY option_status DESC,`id` ASC (4 sor: 0,0003 mp/0,0045 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0005 mp/0,0049 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0003 mp/0,0052 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0053 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0007 mp/0,0061 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0003 mp/0,0064 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0002 mp/0,0066 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=1) LIMIT 1 (1 sor: 0,0003 mp/0,0070 mp)
SELECT pageview
FROM alz_mag_article_pageview
WHERE domain_id = '1' AND mag_article_id = '671' (1 sor: 0,0006 mp/0,0076 mp)
UPDATE alz_mag_article_pageview
SET pageview = pageview + 1
WHERE domain_id = ? AND mag_article_id = ? (1 sor: 0,0004 mp/0,0080 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0007 mp/0,0087 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0004 mp/0,0091 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0092 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0005 mp/0,0097 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0003 mp/0,0100 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0003 mp/0,0103 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (8 sor: 0,0011 mp/0,0114 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=270) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0007 mp/0,0121 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=257) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0007 mp/0,0128 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=108) AND ((option_submenu=1) OR (option_mainmenu=1)) (8 sor: 0,0013 mp/0,0141 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=145) AND ((option_submenu=1) OR (option_mainmenu=1)) (10 sor: 0,0009 mp/0,0150 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=165) AND ((option_submenu=1) OR (option_mainmenu=1)) (12 sor: 0,0010 mp/0,0160 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=202) AND ((option_submenu=1) OR (option_mainmenu=1)) (17 sor: 0,0008 mp/0,0168 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=248) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0174 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=250) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0178 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0005 mp/0,0182 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0003 mp/0,0185 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (8 sor: 0,0007 mp/0,0193 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=109) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0196 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=110) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0199 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=111) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0201 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=112) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0204 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=113) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0208 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=136) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0004 mp/0,0212 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=114) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0004 mp/0,0216 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=267) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0221 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (10 sor: 0,0007 mp/0,0228 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=146) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0007 mp/0,0235 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=147) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0238 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=148) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0241 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=149) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0244 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=116) AND ((option_submenu=1) OR (option_mainmenu=1)) (1 sor: 0,0003 mp/0,0247 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=150) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0250 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=151) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0253 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=152) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0255 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=153) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0258 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=266) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0262 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (12 sor: 0,0007 mp/0,0269 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=166) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0273 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=167) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0276 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=168) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0279 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=169) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0281 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=226) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0005 mp/0,0286 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=140) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0289 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=242) AND ((option_submenu=1) OR (option_mainmenu=1)) (5 sor: 0,0005 mp/0,0293 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=193) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0004 mp/0,0297 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=142) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0302 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=144) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0306 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=239) AND ((option_submenu=1) OR (option_mainmenu=1)) (1 sor: 0,0005 mp/0,0312 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=268) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0315 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (17 sor: 0,0010 mp/0,0325 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=203) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0006 mp/0,0331 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=172) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0337 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=207) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0005 mp/0,0342 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=171) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0008 mp/0,0350 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=173) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0004 mp/0,0354 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=212) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0358 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=178) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0004 mp/0,0362 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=221) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0366 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=265) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0004 mp/0,0370 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=222) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0375 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=216) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0005 mp/0,0380 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=200) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0384 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=224) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0388 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=143) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0392 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=225) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0397 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=201) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0401 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=269) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0407 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0006 mp/0,0412 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0004 mp/0,0416 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0003 mp/0,0419 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0002 mp/0,0421 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0422 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0004 mp/0,0426 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0002 mp/0,0429 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0003 mp/0,0432 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=250) LIMIT 1 (1 sor: 0,0004 mp/0,0435 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=248) LIMIT 1 (1 sor: 0,0003 mp/0,0438 mp)
SELECT SQL_CALC_FOUND_ROWS * FROM alz_mag_article
WHERE option_status = 'published'
AND date_publish > 0
AND option_suggest = 1
ORDER BY date_publish DESC
LIMIT 0,5 (0 sor: 0,0029 mp/0,0467 mp)
FUTÁSI IDŐK SQL: 0,0467 mp
Oldal: 0,2745 mp
Andrea\Core\Site.generate(): 0,2215 mp
Andrea\Core\Site.show(): 0,2263 mp
Felejtek.hu
