Az idegsejtek öregedése lehet a kulcs több betegségben
Szemlézte: Pöltz Ágnes
2021.04.23. 12:25
Testünk legtöbb sejtjével ellentétben az idegsejtek évtizedekig élnek. Mivel ezek az agysejtjeink nem képesek örökítőanyaguk, a DNS megsokszorozására, ezért folyamatosan javítják az állományukon esett károsodásokat. Ahogyan öregednek, egyre kevésbé hatékonyak ezek a javítómechanizmusaik, ami feltételezhetően utat engedhet az Alzheimer-kór és a Parkinson-kór kialakulásának is.
A tudomány már eddig is ismerte a károsodások állandó javításának jelenségét az agyban. Egy új vizsgálat szerint ez a tevékenység azonban nem véletlenszerű, hanem vannak olyan speciális területek, amelyek a feltevések szerint különös jelentőséggel bírnak. Az idegsejtek ezeket a területeket igyekeznek elsőként rendbe hozni az örökítőanyagon.
A Science tudományos szakfolyóiratban közölt cikk egészen újszerű betekintést enged az agy öregedésének és betegségeinek genetikai hátterébe, ezzel pedig lehetőség kínálkozik ara, hogy az Alzheimer-kór, Parkinson-kór és más demenciához kapcsolódó betegségek kezelésére is hatékony beavatkozásokat alakíthassunk ki.
Dr. Rusty Gage professzor, a publikáció szerzője úgy nyilatkozott, hogy felfedezésük legfontosabb tanulsága abban áll, miszerint az agy genetikai állományában vannak olyan pontok, amik kiemelt figyelmet kapnak az agy öngyógyító folyamataiban. Ezen területek ismeretében pedig lehetővé válik majd olyan terápiák kidolgozása, amik éppen ezeket a genetikai területeket célozzák meg.
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Felejtek.hu
