Az idegsejtek öregedése lehet a kulcs több betegségben
Szemlézte: Pöltz Ágnes
2021.04.23. 12:25
Testünk legtöbb sejtjével ellentétben az idegsejtek évtizedekig élnek. Mivel ezek az agysejtjeink nem képesek örökítőanyaguk, a DNS megsokszorozására, ezért folyamatosan javítják az állományukon esett károsodásokat. Ahogyan öregednek, egyre kevésbé hatékonyak ezek a javítómechanizmusaik, ami feltételezhetően utat engedhet az Alzheimer-kór és a Parkinson-kór kialakulásának is.
A tudomány már eddig is ismerte a károsodások állandó javításának jelenségét az agyban. Egy új vizsgálat szerint ez a tevékenység azonban nem véletlenszerű, hanem vannak olyan speciális területek, amelyek a feltevések szerint különös jelentőséggel bírnak. Az idegsejtek ezeket a területeket igyekeznek elsőként rendbe hozni az örökítőanyagon.
A Science tudományos szakfolyóiratban közölt cikk egészen újszerű betekintést enged az agy öregedésének és betegségeinek genetikai hátterébe, ezzel pedig lehetőség kínálkozik ara, hogy az Alzheimer-kór, Parkinson-kór és más demenciához kapcsolódó betegségek kezelésére is hatékony beavatkozásokat alakíthassunk ki.
Dr. Rusty Gage professzor, a publikáció szerzője úgy nyilatkozott, hogy felfedezésük legfontosabb tanulsága abban áll, miszerint az agy genetikai állományában vannak olyan pontok, amik kiemelt figyelmet kapnak az agy öngyógyító folyamataiban. Ezen területek ismeretében pedig lehetővé válik majd olyan terápiák kidolgozása, amik éppen ezeket a genetikai területeket célozzák meg.
Iratkozzon fel hírlevelünkre!
Harmadik fél részére nem adjuk ki az e-mail címét!
NYOMKÖVETÉS (string) «https://work1.felejtek.hu»
(string) «{modul:wd_article}»
INCLUDE MODUL: felejtek_meta CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_meta (0,0026 mp)
INCLUDE MODUL: jsonld CALL: Andrea\Plugins\JsonLD\JsonLD::modul_json_ld (0,0000 mp)
INCLUDE MODUL: owm_daily_mobile MISSED CALL (owm_daily_mobile).
INCLUDE MODUL: felejtek_menu:1 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_menu (0,0476 mp)
INCLUDE MODUL: wd_article CALL: Andrea\Plugins\Webdoki\MagazineArticle::modul_wd_article (0,0022 mp)
INCLUDE MODUL: felejtek_box:250 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_box (0,0005 mp)
INCLUDE MODUL: felejtek_box:248 CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_box (0,0005 mp)
INCLUDE MODUL: basemenu CALL: Andrea\Core\PageList::modul_basemenu (0,0002 mp)
INCLUDE MODUL: comments MISSED CALL (comments).
INCLUDE MODUL: felejtek_related_articles CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_related_articles (0,0000 mp)
INCLUDE MODUL: felejtek_suggested_articles CALL: Andrea\Plugins\Felejtek\Felejtek::modul_felejtek_suggested_articles (0,0024 mp)
MUNKAMENET VÁLTOZÓ array (
'SID' => '445c843beb6fb4a67673e437cefc9f8d',
'user' => 'O:16:"Andrea\Core\User":5:{s:8:"login_ok";b:0;s:13:"inner_modules";a:0:{}s:8:"template";s:0:"";s:5:"items";N;s:8:"' . "{debug_info}" . '*' . "{debug_info}" . 'props";a:4:{s:7:"message";s:0:"";s:10:"user_group";O:21:"Andrea\Core\UserGroup":4:{s:13:"inner_modules";a:0:{}s:8:"template";N;s:5:"items";N;s:8:"' . "{debug_info}" . '*' . "{debug_info}" . 'props";a:0:{}}s:15:"registered_date";s:0:"";s:8:"topic_id";a:0:{}}}',
'lang' => 'hu',
'currency' => 'huf',
'a' => 'cikk',
'p' => '1',
'article' => 671,
'template_path' => '/templates/felejtek2023',
)KIKÜLDÖTT SQL KÉRÉSEK PDO connected to localhost.
SET SESSION `character_set_client` = 'utf8' (0 sor: 0.0001 mp/0.0001 mp)
SET SESSION `character_set_connection` = 'utf8' (0 sor: 0.0001 mp/0.0002 mp)
SET SESSION `character_set_database` = 'utf8' (0 sor: 0.0001 mp/0.0002 mp)
SET SESSION `character_set_filesystem` = 'utf8' (0 sor: 0.0000 mp/0.0003 mp)
SET SESSION `character_set_results` = 'utf8' (0 sor: 0.0000 mp/0.0003 mp)
SET SESSION `character_set_server` = 'utf8' (0 sor: 0.0000 mp/0.0004 mp)
SET SESSION `collation_connection` = 'utf8_hungarian_ci' (0 sor: 0.0001 mp/0.0004 mp)
SET SESSION `collation_database` = 'utf8_hungarian_ci' (0 sor: 0.0001 mp/0.0005 mp)
SET SESSION `collation_server` = 'utf8_hungarian_ci' (0 sor: 0.0000 mp/0.0005 mp)
SET SESSION `group_concat_max_len` = 1024 (0 sor: 0.0000 mp/0.0006 mp)
SELECT * FROM `alz_core_plugin`
WHERE `domain_id` = ? AND `option_active`=1
ORDER BY `depend_nums` ASC (9 sor: 0.0004 mp/0.0010 mp)
SELECT `name`,`value` FROM `alz_core_param` WHERE domain_id = ? (18 sor: 0.0005 mp/0.0015 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0016 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0017 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0018 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0019 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0019 mp)
SELECT * FROM `alz_mag_topic_right` WHERE `user_id`= (0 sor: 0.0001 mp/0.0020 mp)
SELECT `name`,`value` FROM `alz_core_lang` WHERE domain_id = ? (34 sor: 0.0004 mp/0.0024 mp)
SELECT id FROM alz_core_page WHERE domain_id = ? AND permalink = ? (0 sor: 0,0004 mp/0,0027 mp)
SELECT `theme_id` FROM `alz_core_domain` WHERE `id`=1 (1 sor: 0,0004 mp/0,0031 mp)
SELECT * FROM `alz_core_theme` WHERE (`id`=2) LIMIT 1 (1 sor: 0,0002 mp/0,0034 mp)
SELECT * FROM `alz_mag_topic` ORDER BY option_status DESC,`id` ASC (4 sor: 0,0003 mp/0,0037 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0004 mp/0,0041 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0002 mp/0,0043 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0045 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0014 mp/0,0058 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0002 mp/0,0060 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0002 mp/0,0062 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=1) LIMIT 1 (1 sor: 0,0003 mp/0,0065 mp)
SELECT pageview
FROM alz_mag_article_pageview
WHERE domain_id = '1' AND mag_article_id = '671' (1 sor: 0,0006 mp/0,0071 mp)
UPDATE alz_mag_article_pageview
SET pageview = pageview + 1
WHERE domain_id = ? AND mag_article_id = ? (1 sor: 0,0003 mp/0,0074 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0004 mp/0,0078 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0003 mp/0,0080 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0081 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0004 mp/0,0085 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0002 mp/0,0088 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0002 mp/0,0090 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (8 sor: 0,0006 mp/0,0096 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=270) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0099 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=257) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0103 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=108) AND ((option_submenu=1) OR (option_mainmenu=1)) (8 sor: 0,0004 mp/0,0107 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=145) AND ((option_submenu=1) OR (option_mainmenu=1)) (10 sor: 0,0005 mp/0,0112 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=165) AND ((option_submenu=1) OR (option_mainmenu=1)) (12 sor: 0,0006 mp/0,0118 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=202) AND ((option_submenu=1) OR (option_mainmenu=1)) (17 sor: 0,0007 mp/0,0125 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=248) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0128 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=250) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0131 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0003 mp/0,0134 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0003 mp/0,0137 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (8 sor: 0,0004 mp/0,0142 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=109) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0146 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=110) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0150 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=111) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0153 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=112) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0156 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=113) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0159 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=136) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0004 mp/0,0163 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=114) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0005 mp/0,0167 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=267) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0171 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (10 sor: 0,0005 mp/0,0176 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=146) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0178 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=147) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0181 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=148) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0184 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=149) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0187 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=116) AND ((option_submenu=1) OR (option_mainmenu=1)) (1 sor: 0,0003 mp/0,0190 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=150) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0192 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=151) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0195 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=152) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0005 mp/0,0200 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=153) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0204 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=266) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0207 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (12 sor: 0,0006 mp/0,0214 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=166) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0004 mp/0,0217 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=167) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0220 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=168) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0223 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=169) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0225 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=226) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0004 mp/0,0229 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=140) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0232 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=242) AND ((option_submenu=1) OR (option_mainmenu=1)) (5 sor: 0,0004 mp/0,0235 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=193) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0004 mp/0,0239 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=142) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0241 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=144) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0244 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=239) AND ((option_submenu=1) OR (option_mainmenu=1)) (1 sor: 0,0003 mp/0,0247 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=268) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0250 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (17 sor: 0,0007 mp/0,0257 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=203) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0004 mp/0,0261 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=172) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0263 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=207) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0003 mp/0,0266 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=171) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0268 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=173) AND ((option_submenu=1) OR (option_mainmenu=1)) (4 sor: 0,0004 mp/0,0272 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=212) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0002 mp/0,0275 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=178) AND ((option_submenu=1) OR (option_mainmenu=1)) (6 sor: 0,0003 mp/0,0278 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=221) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0281 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=265) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0003 mp/0,0284 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=222) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0287 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=216) AND ((option_submenu=1) OR (option_mainmenu=1)) (3 sor: 0,0004 mp/0,0290 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=200) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0293 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=224) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0296 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=143) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0299 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=225) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0302 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=201) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0305 mp)
SELECT * FROM `alz_core_page` WHERE (`parent_id`=269) AND ((option_submenu=1) OR (option_mainmenu=1)) (0 sor: 0,0003 mp/0,0308 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0004 mp/0,0312 mp)
SELECT * FROM `alz_core_page`
WHERE (`option_submenu` = 1) AND (`parent_id` = ?)
ORDER BY `bearing` DESC,`title` ASC (0 sor: 0,0003 mp/0,0315 mp)
SELECT * FROM `alz_mag_article` WHERE (`id`=671) LIMIT 1 (1 sor: 0,0003 mp/0,0318 mp)
SELECT id FROM `alz_mag_topic` WHERE parent_id = '2' (0 sor: 0,0002 mp/0,0320 mp)
UPDATE `alz_mag_topic`
SET `permalink` = ''
WHERE `id` = (0 sor: 0,0001 mp/0,0321 mp)
SELECT GROUP_CONCAT(keyword) FROM alz_mag_article_keyword WHERE mag_article_id = '671' GROUP BY mag_article_id (0 sor: 0,0003 mp/0,0324 mp)
SELECT permalink FROM alz_mag_category WHERE id = '1' (1 sor: 0,0002 mp/0,0326 mp)
SELECT * FROM alz_mag_category WHERE id IN (1) ORDER BY title (1 sor: 0,0002 mp/0,0328 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=250) LIMIT 1 (1 sor: 0,0002 mp/0,0331 mp)
SELECT * FROM `alz_core_page` WHERE (`id`=248) LIMIT 1 (1 sor: 0,0002 mp/0,0333 mp)
SELECT SQL_CALC_FOUND_ROWS * FROM alz_mag_article
WHERE option_status = 'published'
AND date_publish > 0
AND option_suggest = 1
ORDER BY date_publish DESC
LIMIT 0,5 (0 sor: 0,0023 mp/0,0357 mp)
FUTÁSI IDŐK SQL: 0,0357 mp
Oldal: 0,3125 mp
Andrea\Core\Site.generate(): 0,2611 mp
Andrea\Core\Site.show(): 0,2658 mp
Felejtek.hu
