A demencia egy formája lehet a hosszú Covid?
Szemlézte: Pöltz Ágnes
2022.02.13. 09:45
Egy frissen végzett, kis méretű vizsgálat eredményei szerint a Covidban elhunytak egy részének agyában olyan elváltozásokat találtak, amik az alzheimeresekre is jellemzőek.
A Columbia Egyetem kutatói szerint mindez azért is lényeges, mert megmagyarázhatja a hosszú Covidban szenvedők által átélt emlékezeti nehézségeket.
A tudósokat éppen ez a „ködös” gondolkodási tünet sarkallta arra, hogy közelebbről megvizsgálják az agy egy bizonyos molekulájának, a rianodin receptorok működését Covidban. A vizsgálatot vezető Dr.Andrew Marks elmondta, hogy a rianodin receptorok szerepét már ismerik, ugyanis többek között a stresszre és az Alzheimer-kórra adott agyi válaszban is jelen van.
A tanulmány szerzői összesen tíz, Covidban elhunyt beteg agyát vizsgálták meg. Többek esetében tapasztalták a fenti jellegzetes, Alzheimer-kórban is megfigyelhető receptorváltozást, valamint a szintén a betegségben megjelenő úgynevezett tau-csomókat. Utóbbiakat egyrészt megtalálták azokon a területeken, ahol jellemzően az Alzheimer-kór esetében is elhelyezkednek, ám ezeken kívül az agy más pontjain is felfedezték a tau jelenlétét.
A kutatók szerint ez jól magyarázhatja a hosszú Covidban tapasztalt ködös gondolkodást és memóriaproblémákat.
Az elváltozások közvetítő-mechanizmusa a feltételezések szerint a súlyos fertőzésre adott immunválasz nyomán fellépő agyi gyulladásos folyamat lehet, ami károsítja a rianodin receptorokat és a tau csomók kialakulásához vezet.
Dr. Mark szerint még az is elképzelhető, hogy a hosszú Covid az Alzheimer-kór egy atipikus formája – vagy épp az is elképzelhető lehet, hogy a súlyos covidosok később esendőbbek lehetnek az Alzheimer-kór kialakulására. Ezen feltételezések bizonyítására azonban még sok további vizsgálatra van szükség.
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