A női kromoszómák védhetnek az Alzheimer-betegségben - felejtek.hu

A női kromoszómák védhetnek az Alzheimer-betegségben

Szemlézte: Pöltz Ágnes

2020.09.25. 14:25

Megelőzés

forrás: Alzheimers Research UK

A kaliforniai egyetem tudósai olyan újszerű kutatási eredményeket publikáltak, miszerint a második X kromoszóma védelmet jelenthet az Alzheimer-kór kialakulásával kapcsolatban.

Az emberi gének 23 pár kromoszómába csavarodva találhatóak meg sejtjeinkben. Ezek közül 22 pár mindenkinél egyforma, nemtől függetlenül. A huszonharmadik pár azonban az úgynevezett nemi kromoszóma: nőknél két X, férfiaknál egy X és egy Y kromoszómából épül fel.

A tudósok egereken vizsgálták a nemi kromoszóma és az Alzheimer-kór kialakulása közötti kapcsolatot. Azt találták, hogy a két X kromoszómával rendelkező, az Alzheimer-kór tüneteit mutató egyedeknél magasabb volt a várható élettartam és kisebb az agyi károsodás mértéke. Mindez úgy tűnik, hogy a Kdm6a nevű gén aktivitásának köszönhető, amelyről már emberi agyszövetben is kimutatták, hogy csökkenti a szellemi hanyatlás mértékét.

Fontos ugyanakkor megjegyezni, hogy jelenlegi adataink szerint több nőt, mint férfit érint az Alzheimer-kór. A fenti eredmények tehát nem feltétlenül jelentik azt, hogy a nők védve lennének a betegségtől, hanem inkább arra utalnak, hogy a nők az Alzheimer-kór nyomában bekövetkező változások mellett is hosszabb életre számíthatnak - emelik ki a kutatástól független szakértők.

Habár a fenti és ezekhez hasonló állatkísérletes eredményes még csupán az Alzheimer-kór megértésének és kezelési lehetőségeinek kezdeti lépéseit jelentik, minden egyes eredmény hozzájárul ahhoz, hogy a jövőben gyógymódot, illetve gyógyszert találhassunk a betegségre.

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